Xiuzhu Dong
Ph.D., Professor





Institute of Microbiology
Chinese Academy of Sciences
Datun Rd, Beijing 100101, P. R. China
Tel / Fax: 86-10-64807413
E-mail: dongxz@im.ac.cn

Research Area
Anaerobe resources, molecular phylogenetics and interspecies interaction

Education & Professional Experience
1994, Wageningen University, the Netherlands, Ph D
1995-1996, Postdoctoral fellow at Alabama University, Birmingham, USA
1996-present, Principle investigator and Professor at Institute of Microbiology, CAS
2000, granted with the outstanding young scientist

Current Research
 (i) strain resources and phylogeny of synthophic bacteria in the anaerobic degradation of organic complex, and their interspecies interaction with methanogens; (ii) cold-adapted methanogens and their function in CH4 emission of Tibet plateau wetland under permanent low temperature; and (iii) interspecies interaction between oral streptococci and S. mutans.
Totally 6 novel synthophic bacterial taxa and 3 novel methanogenic archaea have been isolated and validly published. Via Syntrophic metabolism studies bicarbonate has been determined as a new sporulation associated factor.
Phylogenetic analysis based on 16S rRNA and mcrA homologies showed that methyl-trophic methanogens could be predominant in Zoige wetland soil, including uncultured methanogen cluster Z-1. Using quantitative Real-time PCR and FISH, cluster Z-1 was estimated to be account for 15-25% of the total methanogens.
Study on the interspecies interaction between a tentative oral commensal S. oligofermentans and S. mutans showed that the former could convert the lactic acid produced by S. mutans to H2O2, then in turn to inhibit the growth of S. mutans, thus developing a “counteroffensive strategy” to win the interspecies competition.


Recent publications
1. Huichun Tong, Wei Chen, Justin Merritt, Fengxia Qi, Wenyuan Shi, Xiuzhu Dong*. Streptococcus oligofermentans inhibits Streptococcus mutans through conversion of lactic acid into inhibitory H2O2: a possible counteroffensive strategy for inter-species competition. Molecular Microbiology 63(3):872-880,2007.
2. Chenggang Wu, Xiaoli Liu and Xiuzhu Dong Syntrophomonas wolfei subsp. methylbutyratica subsp. nov., and assignment of Syntrophomonas wolfei subsp. saponavida to Syntrophomonas saponavida sp. nov. comb. nov. Sys. Appl. Microbiol. 2007 (in press).
3. Tong, Hui; Zhu, Baoli; Chen, Wei; Qi, Fengxia; Shi, wenyuan; Dong, Xiuzhu Establishing a Genetic System for Ecological Studies of Streptococcus oligofermentans. FEMS Microbiology Letters 264: 213–219, 2006.
4. Chenggang Wu,Xiaoli Liu and Xiuzhu Dong Syntrophomonas cellicola sp. nov., a novel sporeforming syntrophic bacterium isolated from a distilled-spirit-fermenting cellar and assignment of Syntrophospora bryantii to Syntrophomonas bryantii sp. nov., comb. nov. Inter. J. System. Evolution. Microbiol. 56(10)2331-2335.2006.
5. Kai Ma, Xiaoli Liu, Xiuzhu Dong Methanosaeta harundinacea, sp. nov., a novel acetate-scavenging methanogen isolated from a UASB reactor. Inter. J. System. Evolution. Microbiol. 56: 127-131,2006.

Laboratory Staff

Huichun Tong   Associate Professor

Xiaoli Liu   Senior technician

Graduate Students  
Jinxing Zhu, 2005-2010 
Guishan Zhang, 2006-2009
Kegui Zhgang, 2003-2008
Lili Niu, 2004-2007
Wei Chen, 2004-2007
Lei Song, 2005-2008
Shichun Cai, 2004-2009
Jia Bao Li, 2007-2010