George Fu Gao
DVM, DPhil (Oxon)
Professor
Director-General

 

 

Grants

Other Titles

Awards and Honors

Patents

Publications

Laboratory Staff

Postdoctoral Fellows

Graduate Students

 

 

Institute of Microbiology
Chinese Academy of Sciences
Tel: 86-10-64807569
E-mail: gaof@im.ac.cn

Brief Biograph
DVM, BSc, Shanxi Agricultural University, China, 1983
MSc, Beijing Agricultural University, China, 1986
PhD (DPhil-Oxon), Oxford University, UK, 1995
Oxford University, 1995-1998, with Prof. John I Bell, Prof. Andrew J McMichael and Dr Bent K Jakobsen
Calgary University, Canada, 1994 (3months), with Dr Robert B Bell
Harvard University, 1999-2001, with Prof. Don C Wiley and Prof. Stephen C Harrison

Career
Lecturer, Beijing Agricultural University, 1986-1991
Lecturer, Oxford University, 2001-2004
Professor and Director-General, Institute of Microbiology, Chinese Academy of Sciences

Research Interests
Gao’s lab is interested in protein-protein interactions related to molecular virology and molecular immunology and molecular epidemiology and molecular phylogeny of zoonotic pathogens, Particularly the lab is working on (1) the molecular basis on how enveloped viruses, e.g. avian influenza virus, HIV, SARS coronavirus, paramyxovirus (e.g., Sendai virus and Newcastle disease virus), get into the host cells. There are a series of events happening in this process, involving host-virus protein-protein interaction and protein conformational changes; (2) the molecular basis of T cell (the second arm of the immune system after the B-cell antibody system) antigen recognition. Again there are a lot of protein-protein interactions, both between the cell membranes and inside the cells; (3) viral proteins interacting with host cellular proteins, esp. Those involved in virus distinct pathogenesis and effects on host immune response. (4) Molecular basis of interspecies transmission and molecular epidemiology of zoonotic pathogens. Over 80 publications in the related fields involved in the journals:Nature, Science, Nature Medicine, PLoS Medicine, PLoS one, Lancet, Immunology Today, Trends in Immunology, Immunity, Proceedings of National Academy of Sciences-USA, Journal of Experimental Medicine, Journal of Biological Chemistry, journal of Immunology etc.

Grants
1. National Key Technologies R&D Program
2. Chinese Academy of Sciences (CAS) “Hundred-talent Project”
3. Chinese Academy of Sciences (CAS) President Foundation
4. The National Natural Sciences Foundation of China (NSFC)
5. The Key Project of the Knowledge Innovation Program of Chinese Academy of Sciences (CAS).
6. National Program on Key Basic Research Projects (973) (Chief scientist)

Other Titles
1. Visiting Professor, China Agriculture University
2. Guest Professor, Wu Han University
3. Vice-president, Asian Consortium for the Conservation and Sustainable Use of
  Microbial Resources (ACM)
5. Editorial board, Pharmaceutical Biotechnology
6. Executive vice-President, Biotechnology Society of China
7. Executive Councilor, China Preventive Medicine Association.

Awards and Honors
1. Young Scientist Award, Chinese Association of Sciences and Technology (CAST), 1988
2. Sino-British Friendship Scholarship Scheme Fellowship, 1991
3. Wellcome Trust International Travelling Fellowship, 1998
4. Outstanding Young Investigator (Overseas), National Natural Science Foundation of China NSFC, 2002
5. "One-Hundred Talent" Investigator, Chinese Academy of Sciences (CAS), 2004
6. Distinguished Young Investigator, NSFC, 2005
7. Chief Scientist, National Frontier Science Program 973, Ministry of Science and Technology “MOST”, China, 2005

Patents
1. CD8 as an inhibitor of the cellular immune system, PCT/GB 98/03235 (1997) (with Gerth, U.C., Sewell, A.K., Bell , J.I. and Jakobsen, B.K.).
2. Soluble T cell receptor, PCT/GB 9810759.2 (1998) (with Willcox B.E., Boulter, J.M., Bell , J.I and Jakobsen, B.K.).
3. Heat-shock protein gp96 and HBV peptide complex used for HBV-induced hepatic carcinoma, PCT/CN01/00295 (2000) (with Meng, S.-D. and Tien, P.).
4. Potent peptide inhibitors for SARS coronavirus, 2003, China application No.03136220.6 (with Tien, P., Zhu, J., Xiao, G. & Zheng, C.).

Publications

  1. Chen, C, Tang, J, Dong, W, Wang, C, Feng, Y, Wang, J, Zheng, F, Pan, X, Liu, D, Li, M, Song, Y, Zhu, X, Sun, H, Feng, T, Guo, Z, Ju, A, Ge, J, Dong, Y, Sun, W, Jiang, Y, Wang, J, Yan, J, Yang, HM, Wang, X*, Gao*, G.F., Yang, R*, Wang, J*, Yu, J*, 2007, A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates, PLoS ONE, 2: e315
  2. Cole, DK, Rizhallah, PJ, Boulter, JM, Sami, M, Vuidepot, AL, Glick, M, Gao, F, Bell, JI, Jakobsen*, BK, Gao*, G.F., 2007, Computational design and crystal structure of an enhanced affinity mutant human CD8aa coreceptor, PROTEINS: Structure, Function, and Bioinformatics, 67 (1), 65-74 (with front cover illustration)
  3. Chu, F, Lou, Z, Chen, YW, Liu, Y, Zong, L, Gao, B, Khan, AH, Bell, JI, Rao, Z and Gao*, G.F., 2007, First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape, The Journal of Immunology, 178 (2), 2007, 944-952.
  4. Chang, S, Zhang, J, Liao, X, Zhu, X, Wang, D, Zhu, J, Feng, T, Zhu, B, Gao, G.F, Wang, J, Yang, HM, Yu, J* and Wang, J*, 2007, Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research, Nucleic Acids Research, 35 (Database issue), D376-80.
  5. Zhang, JY, Zhang, Z, Wang, X, Fu, JL, Yao, J, Jiao, Y, Chen, L, Zhang, H, Wei, J, Jin, L, Shi, M, Gao, G.F, Wu, H, Wang*, FS, 2007, PD-1 upregulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors, but not in long-term non-progressors, Blood (In press)
  6. Cole, DK, Pumphrey, NJ, Boulter, JM, Sami, M, Bell, JI, Gostick, E, Price, DA, Gao, G.F, Sewell, AK, Jakobsen, BK, 2007, Human T-cell receptor binding affinity is governed by major histocompatibility complex class restriction, The Journal of Immunology (In press)
  7. Fan, Z, Zhuo, Y, Tan, X, Zhou, Z, Yuan, J, Qiang, B, Yan, J, Peng, X, Gao*, G.F, 2006, SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system, Journal Medical Virology, 78 (11), 1365–1373
  8. Lou, Z, Xu, Y, Xiang, K, Su, N, Qin, L, Li, X, Gao, G.F, Bartlam, M and Rao*, Z, 2006, Crystal structures of Nipah and Hendra virus fusion core proteins, FEBS Journal, 273 (19), 4538–4547
  9. Liu, Y, Xu, Y, Lou, Z, Zhu, J, Hu, X, Gao*, G.F, Qiu*, BS, Rao*, Z, Tien, P*, 2006, Structural characterization of Mumps virus fusion protein core, Biochemical and Biophysical Research Communications, 348 (3), 916–922
  10. Zhou, M, Xu, D, Li, X, Li, H, Shan, M, Tang, JR, Wang, M, Wang, FS, Zhu, X, Tao, H, He, W, Tien, P*, and Gao*, G.F, 2006, Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes, The Journal of Immunology, 177 (4), 2138-2145
  11. Kannan, S, Audet, A, Knittel, J, Mullegama, S, Gao, G.F and Wu, M*, 2006, Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. European Journal of Immunology, 36 (7), 1739-1752
  12. Zhang, Y, Zan, Y, Shan, M, Liu, C, Shi, M, Li, W, Zhang, Z, Liu, N, Wang, F, Zhong, W, Liao, F, Gao*, G.F, Tien, P*, 2006, Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion, Biochemical and Biophysical Research Communications, 344 (2), 581–587
  13. Tang*†, J, Wang†, C, Feng†, Y, Yang†, W, Song†, H, Chen†, Z, Yu†, H, Pan, X, Zhou, X, Wang, H, Wu, B, Wang, H, Zhao, H, Lin, Y, Yue, J, Wu, Z, He, X, Gao, F, Khan, AH, Wang, J, Zhao, GP, Wang*, Y, Wang*, X, Chen, Z, Gao*, G.F, 2006, Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Medicine,3 (5), 668-676 (†shared the first author) (With short title in the front cover: Streptococcus suis outbreak in China)
  14. Li X, Liu X, Sun F, Gao J, Zhou H, Gao GF, Bartlam M, Rao Z. 2006,Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor.  Biochemical and Biophysical Research Communications. 339(1):407-14
  15. Cole, DK, Rizkallah, PJ, Gao, F, Watson, NI, Boulter, JM, Bell, JI, Sami, M, Gao*, G.F & Jakobsen*, BK, 2006, Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology, 36 (1), 170-179
  16. Liu*†, J, Xiao†, H, Lei†, F, Zhu, Q, Qin, K, Zhang, XW, Zhang, XL, Zhao, D, Wang, G, Feng, Y, Ma, J, Liu, W, Wang, J, Gao*, G.F, 2005, Highly pathogenic H5N1 influenza virus infection in migratory birds.Science,309 (5738), 1206 (†shared the first author)
  17. Ni, L, Zhao, L, Qian, Y, Zhu, J, Jin, Z, Chen, YW, Tien, P*, Gao*, G.F, 2005, Design and characterization of human respiratory syncytial virus entry inhibitors. Antiviral Therapy, 10 (7), 833-840
  18. Zhu, J, Jiang, X, Liu, Y, Tien, P*, Gao*, G.F, 2005, Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. Journal of Molecular Biology, 354 (3), 601-613
  19. Ni, L, Zhao, L, Gao, G.F, Qian, Y*, Tien, P*, 2005, The antibodies directed against N-terminal heptad-repeat peptide of hRSV fusion protein and its analog-5-Helix inhibit virus infection in vitro. Biochemical and Biophysical Research Communications, 331 (4), 1358-1364
  20. Ni, L, Gao*, G.F, Tien, P*, 2005, Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics. Biochemical and Biophysical Research Communications,332 (3), 831-836
  21. Zhang, Z, Xu, D, Li, Y, Jin, L, Shi, M, Wang, M, Zhou, X, Wu, H, Gao, G.F, Wang*, FS, 2005, Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunology, 116 (3), 225-35
  22. Chu, F, Lou, Z, Gao, B, Bell, JI, Rao, Z, Gao*, G.F, 2005, Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 61 (Pt6), 614–616
  23. Li, H, Zhou, M, Han, J, Zhu, X, Dong, T, Gao*, G.F, and Tien, P* , 2005, Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. The Journal of Immunology;174(1):195-204
  24. Gao*, G.F, 2005, Filling the hole: evidence of a small molecule binding to the fusion core pocket in human respiratory syncytial virus. Expert Opinion on Investigational Drugs 14(2): 195-197
  25. Yuan, F., Lou, Z., Li, X., Chen, Y., John I. Bell, Zihe Rao, Gao*, G.F , 2005, Refolding,crystallization and preliminary X-ray structural studies of the West Nile virus envelope(E) protein domain Ⅲ. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61,421-423
  26. Li, S., Zhu, J., Peng, Y., Cui, S., Wang, C., Gao*, G.F, Tien, P*. 2005, Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion. Biochemical and Biophysical Research Communications (BBRC)329: 603-609
  27. Cole, DK, Rizkallah, PJ, Sami, M, Lissin, NM, Gao, F., Bell, JI, Boulter, JM, Glick, M, Vuidepot, AL, Jakobsen, BK and Gao*, G.F, 2005, Crystallization and preliminary X-ray structural studies of a high-affinity CD8ααco-receptor to pMHC. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 61 (Pt 3), 285-287.
  28. Ni, L., Zhu, J., Zhang, J., Yan, M., Gao*, G.F, Tien, P*, 2005, Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. Biochemical and Biophysical Research Communications (BBRC)330: 39-45.
  29. Wang, X., Bai, Y., Zhang, G., Zhao, J., Wang, M., Gao*, G.F. 2005, Structure and function study of paramyxovirus fusion protein heptad repeat peptides. Archives of Biochemistry and Biophysics(ABB) 436: 316-322
  30. Xu,D.,Zhang,Z.,Jin,L.,Chu,F.,Mao,Y.,Wang,H.,Liu,M.,Wang,M.,Zhang,L., G.F. Gao and Wang,F.S.2005,Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. European Journal of Clinical Microbiology & Infectious Diseases 24:165-171
  31. Liu Y, Xu Y, Zhu J, Qiu B, Rao Z, Gao, G.F, Tien P, Crystallization and preliminary X-ray diffraction analysis of central structure domains from mumps virus F protein. 2005, Acta Crystallograph Sect F Struct Biol Cryst Commun, 61(Pt 9):855-7
  32. Xu, Y., Lou, Z., Liu, Y., Pang, H., Tien, P., Gao, G.F, & Rao*, Z., 2004 , Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. Journal of Biological Chemistry (JBC) 279(47):49414-9
  33. Xu, Y., Liu, Y., Lou, Z., Qin, L., Li, X., Bai, Z., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Structural basis for coronavirus-mediated virus membrane fusion: crystal structure of MHV spike protein fusion core, Journal of Biological Chemistry (JBC) 279 (29):30514-22.
  34. Cole, D.K. & Gao*, G.F. , 2004, CD8: Adhesion molecule, co-receptor and immuno-modulator (invited review), Cellular and Molecular Immunology 1 (2): 81-88.
  35. Pang, H., Bartlam, M., Zeng, Q., Miyatake, H., Hisano, T., Miki, K., Wong, L-L, Gao, G.F. & Rao, Z., 2004, Crystal structure of human pirin: an iron binding nuclear protein and transcription cofactor. Journal of Biological Chemistry (JBC) 279 (2): 1491-1498.
  36. Xu, D., Zhang, Z., Chu , F., Li, Y., Jin, L., Zhang, L., Gao, G.F. & Wang, F.-S., 2004, Genetic variation of SARS coronavirus in Beijing hospital, Emerging Infectious Diseases 10 (5): 789-794.
  37. Gao, G.F. , 2004, Just folding back: Convergence of viral fusion mechanisms (Monitor), Drug Discovery Today 9: 288.
  38. Xu, Y., Zhu, J., Liu, Y., Lou, Z., Yuan, F., Liu, Y., Cole, D.K., Ni, L., Su, N., Qin, L., Li, X., Bai, Z., Bell, J.I., Pang, H., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus, Biochemistry 43(44):14064-71.
  39. Zhu, X., Li, C., Lang, Z., Gao*, G.F. & Tien*, P., 2004, Significant correlation between expression level of HSP gp96 and the progression of hepatitis B virus induced diseases, World Journal of Gastroenterology 10 (8): 1141-1145.
  40. Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Qin, L., Li, X., Bai, Z., Yuan, F., Rao*, Z. & Gao*, G.F. , 2004,Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification 38(1):116-22.
  41. Xu, Y., Gao, S., Cole, D.K., Zhu, J., Su, N., Wang, H., Gao*, G.F. & Rao*, Z., 2004, Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses, Biochemical and Biophysical Research Communications (BBRC) 315 (3): 664-670
  42. Zhu, J., Xiao, G., Xu, Y., Yuan, F., Zheng, C., Liu, Y., Cole, D.K., Yan, H., Bell, J.I., Rao, Z., Tien*, P. & Gao*, G.F. , 2004, Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and identification of potent peptide inhibitors, Biochemical and Biophysical Research Communications (BBRC) 319: 283-288.
  43. Liu, Y., Zhu, J., Feng, M., Tien, P. & Gao*, G.F. , 2004, Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein. Archives of Biochemistry and Biophysics (ABB) 421: 143-148.
  44. Yan, H., Xiao, G., Zhang, J., Hu, Y., Yuan, F., Cole, D.K., Zheng*, C. & Gao*, G.F. , 2004, SARS coronavirus induces apoptosis in Vero E6 cells, Journal of Medical Virology 73: 323-331.
  45. Xu, Y., Lou, Z., Liu, Y., Cole, D.K., Su, N., Qin, L., Li, X., Bai, Z., Rao, Z. & Gao*, G.F. , 2004, Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallographica Section D Biological Crystallography D60: 1161-1164 .
  46. Zhou, M., Xu, Y., Lou, Z., Cole, D.K., Li, X., Liu Y.,Tien, P., Rao*, Z. & Gao*, G.F. , 2004, complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2 k d complexed with an HBV core nonapeptide, Acta Crystallographica Section D Biological Crystallography 60(Pt 8):1473-5.
  47. Wang, X., Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Rao, Z., Wang*, M. & Gao*, G.F. , 2004, Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein, Acta Crystallographica Section D Biological Crystallography 60(Pt 9):1632-5.
  48. Xu, Y., Bai, Z., Qin, L., Li, X., Gao*, G.F. & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the fusion core of the spike protein of the murine coronavirus mouse hepatitis virus (MHV). Acta Crystallographica Section D Biological Crystallography 60 (Pt 11):2013-5.
  49. Xu, Y., Su, N., Qin, L.,Bai, Z., Gao, G.F. , & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein. Acta Crystallographica Section D Biological Crystallography D60 (Pt 12 Pt 2):2377-9.
  50. 王晓佳,张卫红,汪明,高福,2004,囊膜病毒膜融合的分子机制。生物化学与生物物理进展 31(6):482-491 。
  51. Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L.,Ye, S., Pang, H., Gao, G.F. , Anand, K., Bartlam, M., Hilgenfeld, R. & Rao, Z., 2003, The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proceedings of National Academy of Sciences USA (PNAS) 100 (23): 13190-13195.
  52. Ding, Y., Xu, G., Yang, M., Yao , M., Gao, G.F. , Wang, L., Zhang, W. & Rao, Z., 2003, Crystal structure of the ectodomain of human FcRI. Journal of Biological Chemistry (JBC) 278 (30): 27966-27970. (with front cover illustration).
  53. Wang, E., Sun, X., Qian Y., Zhao, L., Tien, P. & Gao* , G.F. , 2003, Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. Biochemical and Biophysical Research Communications (BBRC) 302: 469-475.
  54. Zhu, J., Ding, Y., Gao, F., Wu, T., Zhang, C.W.-H., Tien, P., Rao, Z. & Gao* , G.F. , 2003, Crystallization and preliminary X-ray crystallographic analysis of the trimer core from measles virus fusion protein. Acta Crystallographica Section D Biological Crystallography D59: 587-590.
  55. Li, P., Zhu, J., Wu, B., Gao, F., Tien, P., Rao, Z. & Gao*, G.F. , 2003, Crystallization and preliminary X-ray diffraction analysis of post-fusion 6-helix bundle core structure from Newcastle disease virus F protein. Acta Crystallographica Section D Biological Crystallography D59: 1296-1298.
  56. Zhu, J., Li, P., Wu, T., Gao, F., Ding Y., Zhang, C.W.-H., Rao, Z., Gao*, G.F. & Tien*, P., 2003, Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein. Protein Engineering 16: 373-379. *Shared correspondence author.
  57. Zhu, J., Zhang, C.W.-H., Rao, Z., Tien, P. & Gao*, G.F. , 2003, Biochemical and biophysical analysis of heptad repeat regions from the fusion protein of Menangle virus, a newly emergent paramyxovirus. Archives of Virology 148: 1301-1316.
  58. Gao,* G.F. , Rao, Z. & Bell, J.I., 2002, Molecular coordination of cβ T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends in Immunology 23: 408-413. *Correspondence author
  59. Gao, G.F ., 2002, CD8αα and CD8 αβ: truly different? (News and comment). Trends in Immunology 23: 177.
  60. Gao, G.F. & Rao, Z., 2002, Seeing the change: TCR binds pMHC with an ‘induced-fit' (News and comment). Trends in Immunology 23: 281.
  61. Rao, Z. & Gao, G.F. , 2002, Lipid-antigen presentation by CD1 is crystal clear (News and comment). Trends in Immunology 23: 473.
  62. Jiang, S., Borthwick , N.J. , Morrison, P., Gao, G.F. & Steward, M.W., 2002, Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus . Journal of General Virology 83: 429-438.
  63. Yu, M., Wang, E., Liu, Y., Cao, D., Jin, N., Zhang, C.W.-H, Bartlam, M., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus . Journal of General Virology 83: 623-629.
  64. Zhu, J., Zhang, C.W.-H., Qi, Y., Tien, P. & Gao*, G.F. , 2002, The fusion protein core of measles virus forms stable coiled coil trimer. Biochemical and Biophysical Research Communications (BBRC) 299: 897-902.
  65. Meng, S.-D., Song, J., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. Journal of Immunological Methods 264: 29-35.
  66. Meng, S.-D., Gao, T., Gao, G.F. & Tien*, P., 2001, HBV-specific peptide associated with heat-shock protein gp96. The Lancet 357: 528-529.
  67. Lin, C.-L., Sewell, A.K., Gao, G.F. , Whelan, K., Phillips, R.E. & Austyn, J.M., 2000, Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis. Journal of Experimental Medicine 192: 587-593.
  68. Gao, G.F. , Willcox, B.E., Wyer, J.R., Boulter, J.M., O'Callaghan, C.A., Maenaka, K., Stuart, D.I., Jones, E.Y., van der Merwe, P.A., Bell, J.I. & Jakobsen, B.K., 2000, Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8αα Journal of Biological Chemistry (JBC) 275: 15232-15238.
  69. Gao,* G.F. & Jakobsen, B.K., 2000, Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunology Today 21 (12): 630-636. *Correspondence author
  70. Sewell, A.K., Gerth, U.C., Price, D.A., Purbhoo, M.A., Boulter, J.M., Gao, G.F. , Bell, J.I., Phillips, R.E. & Jakobsen, B.K., 1999, Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5: 399-404.
  71. Wyer* J.R., Willcox*, B.E., Gao*, G.F. , Gerth, U.C., Davis, S.J., Bell, J.I., van der Merwe, P.A. & Jakobsen, B.K., 1999, T cell receptor and coreceptor CD8 αα bind peptide-MHC independently and with distinct kinetics. Immunity 10: 219-225. *Shared first author
  72. Maenaka, K., Juji, T., Nakayama, T., Wyer, J.R., Gao, G.F. , Maenaka, T., Zaccai, N.R., Kikuchi, A., Yabe, T., Tokunaga, K., Tadokoro, K., Stuart, D.I., Jones, E.Y. & van der Merwe, P.A., 1999, Killer cell immunoglobulin receptors and T cell receptors bind peptide-Major Histocompatibility Complex class I with distinct thermodynamic and kinetic properties. Journal of Biological Chemistry (JBC) 274: 28329-28334.
  73. Willcox*, B.E., Gao*, G.F. , Wyer, J.R., O'Callaghan, C.A., Jones, E.Y., van der Merwe, P.A., Bell, J.I. & Jakobsen, B.K., 1999, Production of soluble a b T-cell receptor heterodimers suitable for biophysical analysis of ligand binding. Protein Science 8: 2418-2423. *Shared first author
  74. Willcox*, B.E., Gao*, G.F. , Wyer, J.R., Ladbury, J.E., Bell, J.I., Jakobsen, B.K. & van der Merwe, P.A., 1999, TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity 10: 357-365. *Shared first author
  75. McGuire, K., Holmes, E.C., Gao, G.F. , Reid, H.W. & Gould, E.A., 1998, Tracing the origins of louping ill virus by molecular phylogenetic analysis. Journal of General Virology 79: 981-988.
  76. Gao, G.F. , Gerth, U.C., Wyer, J.R., Willcox, B.E., O'Callaghan, C.A., Zhang, Z.H., Jones, E.Y., Bell, J.I. & Jakobsen, B.K., 1998, Assembly and crystallization of the complex between the human T cell coreceptor CD8 a homodimer and HLA-A2. Protein Science 7: 1245-1249.
  77. Gao, G.F. , Tormo, J., Gerth, U.C., Wyer, J.R., McMichael, A.J., Stuart, D.I., Bell, J.I., Jones, E.Y. & Jakobsen, B.K., 1997, Crystal structure of the complex between human CD8 αα and HLA-A2. Nature 387: 630-634. (with front cover illustration and short title in the front cover page: CD8 comes to grips with MHC).
  78. Gao, G.F. , Zanotto, P.M.A., Holmes, E.C., Reid, H.W. & Gould, E.A., 1997, Molecular variation, evolution and geographical distribution of louping ill virus. Acta Virologica 41: 259-268.
  79. Zanotto, P.M.A., Gould, E.A., Gao, G.F. , Harvey, P.H. &. Holmes, E.C., 1996, Population dynamics of flaviviruses revealed by molecular phylogenies. Proceedings of National Academy of Sciences USA (PNAS) 93: 548-553.
  80. Zanotto, P.M.A., Gao, G.F. , Gritsun, T.S., Marin, S., Jiang, W.R., Venugopal, K., Reid, H.W. & Gould, E.A., 1995, An arbovirus cline across the Northern Hemisphere. Virology 210: 152-159.
  81. Marin, M.S., McKenzie, J., Gao, G.F. , Reid, H.W., Antoniadis, A. & Gould, E.A., 1995, The virus causing encephalomyelitis in sheep in Spain : a new member of the tick-borne encephalitis group. Research in Veterinary Science 58: 11-13.
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Laboratory Staff
Jinghua Yan  Associate Professor     Yanjh@sun.im.ac.cn
Zheng Fan Assistant Professor         Fanzh@sun.im.ac.cn
Yan Wu          secretarylab@im.ac.cn

Postdoctoral Fellows
Jiao Pan,             2004
Di Liu,                 2005
Lili Zong,             2005

Graduate Students

Fuliang Chu,          2004-2007 
Haixia Xiao,           2004-2007
Youjun Feng,         2004-2007
Shuofu Mi,             2004-2007
Jun’e Liu,               2005-2008
Xiaohui Song,        2005-2008
Zhixin Li,                2004-2009
Yong Chen,                2004-2009
Abdul Hamid Khan,    2004-2007
Cheng Liu,                2003-2006
Shujuan Wang,         2004-2007
Zhenhong Guan,       2004-2007
Zhi Zhou,                   2004-2007