Structural Biology Research Group

Principal Investigator

De-Feng Li, Ph. D., Professor

E-mail: lidefeng@im.ac.cn

Research Area

Molecular mechanisms of bacterial adaptation and antibiotics resistances

Research Interests

To address some health related problems, such as degrading the pollutant via microbes and overcoming bacterial antibiotics resistances, we must understand the response of bacteria to environmental conditions. We are interested in the mechanisms of bacteria adaptation to pollutant. As well, we are interested in the mechanisms of bacteria adaption to extreme environments and resisting antibiotics.

Current research includes:

1) The mechanisms of bacteria sensing, moving towards or away from and degrading environmental chemicals, such as aromatic compounds, substrates in Calvin cycle and so on.

2) The regulation mechanism of bacterial movement during biofilm formation and dispersal.

3) The mechanism of bacteria fighting against antibiotics and the way to overcome bacterial antibiotic resistance.

4) Structural study on proteins involved in bacterial adaptation to extreme environments.

 

Group Members:

Principal Investigator

De-Feng Li, Ph. D., Professor

Institute of Microbiology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, P. R. China

Biography

1997-2001 Wuhan University, B.S.

2001-2006 Institute of Biophysics, Chinese Academy of Sciences, Ph.D

2006-2017 Institute of Biophysics, Chinese Academy of Sciences, Assistant Prof./Associate Prof./Prof.