Laboratory of Extremophiles

Principal Investigator
Dr. Prof. Yanhe Ma

Tel/Fax: 86-10-64807616


Research Area
Our research interest is focused on discovering, understanding and application of extremophiles.

Research Interests
(1)Ecology and taxonomy of extremophiles
(2)Physiological mechanisms of extremophiles' adaptation to extreme environments
(3)Exploration of novel functionality of extremophiles for application.

  Our current ongoing projects include: ……
     Synthetic Cell Factories, 973 Program
     Synthesis and characterize the stress resistance parts, 973 Program
      Biotechnological production of bulk chemicals, 863 Program
     Exploitation and application of extremozymes for green biological process, 863 Program

Lab Members

Principal Investigator

Yanhe Ma, Ph. D., Professor

Ph.D., Fermentation Engineering angnan University, China (2005)
Bachelor of Biology Nankai University, China (1983)

Professional Experience

1983~     Staff member, Institute of Microbiology, CAS
1992       Visiting Scholar, Alicante University, Spain
2001      Visiting Scholar, Leicester University, UK
1999 ~    Professor of Microbiology, IMCAS
2000-2005    Deputy Director, Biotechnology Center, IMCAS
2005-2007    Deputy Director, Center for Bioenergy and Industrial Biotechnology, IMCAS
2007-2012    Deputy Director, State Key Laboratory of Microbial Resources, IMCAS
2008-     Director, National Engineering Lab for Industrial Enzymes

Social and Scientific Responsibilities

Member, ICSP Subcommittee on Taxonomy of Halobacteriaceae
Vice President, Chinese Society of Biotechnology
Secretary-General, China Bioindustry Convention
Chairman, Advisory Committee of National High Technology R&D Program, Industrial Biotechnology
Vice-Chairman, Glycobiotechnology Subcommittee of Chinese Society of Biotechnology
Associate Editor, Saline Systems
Associate Editor, 3Biotech
Associate Editor, Chinese Journal of Bioprocess Engineering
Board member, Applied and Environmental Microbiology

Permanent staff

Yanfen Xue, Professor,
Cheng Zhou, Assistant Professor,
Yan Zhang, Engineer,
Xiaochen Ma, Research Assistant,

Postdoctoral Fellows

Wenying Zhao, 2011-
Jinshan Li, 2008-
Guimin Zhang, 2007-2011
Jiansong Ju, 2006-2009
Jie Li, 2005-2007

Graduate Students

Lei Zhai (Ph. D student)
Kai Jiang (Ph. D student)
Liang Yin (Ph. D student)
Deyong Ge (Ph. D student)
Qi Chang (Ph. D student)
Nilnate Assavasirijinda (Ph. D student)
Hang Zhou (Ph. D student)
Jintong Ye (M.Sc student)
Zhougang Zhang (M.Sc student)
Hongliang Qin (M.Sc student)
Chao Ma (M.Sc student)

Former Graduate Students

Wenxia Liu (2013, M.Sc)
Yajian Song (2013, Ph.D)
Wenqin Bai (2013, Ph.D)
Mingjie Xian (2013, M.Sc)
Kun Li (2013, Ph.D)
Ying Meng (2012, M.Sc)
Chenghua Gao (2012, M.Sc)
Tingting Liao (2011, M.Sc)
Chaoning Liang (2011, Ph.D)
Yueju Zhao (2011, Ph.D)
Lang Rao (2011, Ph.D)
Xiaowei Wang (2010, Ph.D)

Yingying Zheng (2010, Ph.D)
Gang Li (2010, Ph.D)
Cheng Zhou (2010, Ph.D)
Jianguo Hao (2009, M.Sc)
Yonghao Guo (2009, Ph.D)
Quanhui Wang (2009, Ph.D)
Yueling Zhang (2009, Ph.D)
Lingfei Hu (2008, M.Sc)
Sanqing Yuan (2007, M.Sc)
Jun Liu (2006, Ph.D)
Hailian Pan (2006, M.Sc)
Hua Xie (2004, M.Sc)
Dapeng Zhao (2004, M.Sc)
Yan Zeng (2003, M.Sc)
Huapeng Fan (2002, M.Sc)
Weizhou Zhang (2001, M.Sc)

Recent Publication

1) Yajian Song, Yanfen Xue, Yanhe Ma*. 2013. Global Microarray Analysis of Carbohydrate Use in Alkaliphilic Hemicellulolytic Bacterium Bacillus sp. N16-5. PLoS One. 8(1): e54090.
2)  Lang Rao, Yanfen Xue, Yingying Zheng, Jian R. Lu*, Yanhe Ma*. 2013. A Novel Alkaliphilic Bacillus Esterase Belongs to the 13th Bacterial Lipolytic Enzyme Family. PLoS One. 8(4): e60645.
3)  Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. 2012. Cloning, expression and characterization of a novel salt tolerant xylanase from Bacillus sp. SN5. Biotechnol Lett. 34: 2093–2099.
4) Ying Meng, Yanfen Xue, Bo Yu, Chenghua Gao, Yanhe Ma*. 2012. Efficient production of L-lactic acid with high optical purity by alkaliphilic Bacillus sp. WL-S20. Bioresour Technol.116: 334–339.
5)  Guimin Zhang, Shunyi Li, Yanfen Xue, Liangwei Mao, Yanhe Ma*. 2012. Effects of salts on activity of halophilic cellulose with glucomannanase activity isolated from alkaliphilic and halophilic Bacillus sp. BG-CS10. Extremophiles. 16: 35–43.
6)  Lei Zhai, Tingting Liao, Yanfen Xue*, Yanhe Ma. 2012. Bacillus daliensis sp. nov., an alkaliphilic, Gram-positive bacterium isolated from a soda lake. Int J Syst Evol Microbiol. 62: 949–953.
7)  Jinshan Li#, Wei Wang#, Yanhe Ma, Anping Zeng*. 2012. Medium optimization and proteome analysis of (R,R)-2,3-butanediol production by Paenibacillus polymyxa ATCC 12321. Appl Microbiol Biotechnol. DOI 10.1007/s00253-012-4331-6.